References: 1. Bikowski J, Pillai R, Shroot B. The position not the presence of the halogen in corticosteroids influences potency and side effects. J Drugs Dermatol . 2006;5(2):125-130. 2. Del Rosso J, Friedlander SF. Corticosteroids: options in the era of steroid-sparing therapy. J Am Acad Dermatol . 2005; 53(1 Suppl 1):s50-s58. 3. US Food and Drug Administration NDA 017765. Promius Pharma, LLC, Princeton, NJ: Aug 1977. 4. Rosenthal AL. Clocortolone pivalate: a paired comparison clinical trial of a new topical steroid in eczema/atopic dermatitis. Cutis . 1980;25(1):96-98. 5. Kircik LH. A study to assess the occlusivity and moisturization potential of three topical corticosteroid products using the skin trauma after razor shaving (STARS) bioassay. J Drugs Dermatol . 2014;13(5):582-585. 6. Cloderm [package insert]. Princeton, NJ: Promius Pharma, LLC; 2017.
Nolvadex is widely available and one of the easiest items on earth to obtain. In the . it is not classified as controlled substance; however, true legal possession will require a prescription. On the black market, nearly all anabolic steroid suppliers carry the SERM and counterfeits, while possible appear to be very rare. The SERM as with many related items is also available through research chemical labs (RCL’s). These RCL’s have found a loophole in the law that allows them to legally manufacture and sell SERM’s, AI’s, Peptides and many other items so as long as it’s for research only. This allows anyone to make a related purchase without a prescription and legally so. However, many of these RCL’s are very low grade. It’s common for their products to lose potency fast, to be unstable, and in some cases, so heavily concentrated they’re hard to dose. While there is a lot of garbage out there, there are quite a few very good RCL’s on the market. A little digging and you’ll easily find one.
Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.