Otosporin solution is a bactericidal preparation active against all the pathogens commonly found in bacterial infections of the ear. Polymixin B is bactericidal against a wide range of gram negative bacilli including Pseudomonas Spp., Escherichia coli , Enterobacter Spp., Klebsiella Spp., and Haemophilus influenzae . It exerts a bactericidal effect by binding to acid phospholipids in the cell wall and membranes of the bacterium, thereby rendering ineffective the osmotic barrier normally provided by the cell membrane. This leads to escape of the cell contents and the death of the organism.
Wax removal ear drops typically contain some form of oil, which helps to soften waxy buildup in the ears. They may be used alone or used in combination with ear washes to help remove excess wax. Though all people have some earwax , some people produce it in greater amounts and may need to clean out the ears regularly to avoid ear pain . Occasionally when a person cleans the ears, he or she pushes wax onto the eardrum , which can dull sound. If hearing loss is noted, get a doctor’s recommendation before using drops, unless this is a commonly occurring problem noted in the past.
Because P. aeruginosa and S. aureus are common pathogens in otorrhea, they must be considered at the time of treatment selection. Currently, no narrow-spectrum agent is available for the coverage of these two microbes. For the treatment of acute diffuse otitis externa, polymyxin B-neomycin-hydrocortisone combinations and fluoroquinolones are equally effective, and neither treatment carries known risk. The twice-daily dosing schedule of topical fluoroquinolones may improve compliance. When selecting treatment for acute otitis media with perforation, topical fluoroquinolones represent a good first-line option, although not clearly better than traditional topical therapy. For chronic suppurative otitis media topical fluoroquinolones likely represent the best choice because treatment is long, and repeated therapy is common. 18