Paradoxical bronchospasm corticosteroids

Following the introduction of salmeterol in the United Kingdom, three cases of respiratory arrest occurring shortly after patients had been commenced on the drug were reported. 11 At the same time, the United Kingdom Committee on the Safety of Medicines reported 26 cases of deterioration in asthma soon after the introduction of long-acting beta-agonists. 12 Withdrawal of the drug resulted in improvement. Like the cases recorded in New Zealand, such events appear to be sporadic and rare but nevertheless cause concern. They appear to follow a pattern but do not lend themselves easily to explanation either in terms of paradoxical bronchospasm or the advent of tolerance .

The oral median lethal dose of albuterol sulfate in mice is greater than 2,000 mg/kg (approximately 6,300 times the maximum recommended daily inhalation dose for adults on a mg/m 2 basis). In mature rats, the subcutaneous median lethal dose of albuterol sulfate is approximately 450 mg/kg (approximately 2,800 times the maximum recommended daily inhalation dose for adults on a mg/m 2 basis). In young rats, the subcutaneous median lethal dose is approximately 2,000 mg/kg (approximately 13,000 times the maximum recommended daily inhalation dose for adults on a mg/m 2 basis). The inhalation median lethal dose has not been determined in animals.

Paradoxical bronchospasm corticosteroids

paradoxical bronchospasm corticosteroids

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