NSAIDs may also interact with certain herbal preparations sold as dietary supplements. Among the herbs known to interact with NSAIDs are bearberry ( Arctostaphylos uva-ursi ), feverfew ( Tanacetum parthenium ), evening primrose ( Oenothera biennis ), and gossypol, a pigment obtained from cottonseed oil and used as a male contraceptive. In most cases, the herb increases the tendency of NSAIDs to irritate the digestive tract. It is just as important for doctors to know which herbal remedies the patient is taking on a regular basis as it is for doctors to know the other prescription medications which are being taken.
Ligand Pharmaceuticals has patents filed for the manufacture and therapeutic use of certain compounds occupying several stated chemical structures, which are intended for use as selective androgen receptor modulators. The patent is filed under the following designations: US8519158 B2, US8865918, US9359285, US20070254875, US20140005186, US20150099720, and WO2005090282A1. The patents will expire on March 12, 2025. These patents effectively protect any future capitalization upon VK5211 in the market by Viking and Ligand through their licensing agreement. 
Biologics. Technically a subset of DMARDs, biologics are complex drugs that stop inflammation at the cellular level. They are usually given by injection or infusion. Two types of biologics are approved to treat psoriatic arthritis. The first type are called anti-tumor necrosis factor-alpha (TNF-alpha) drugs. They block a specific protein produced by immune cells that signals other cells to start the inflammatory process. These include etanercept, adalimumab, golimumab, infliximab and certolizumab. A second type of biologic, called ustekinumab, blocks interleukin-12 and interleukin-23, two pro-inflammatory proteins. While biologics can be very effective, they suppress the immune system and raise the risk of infections.