NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.
Researchers from Oklahoma State University gave participants either 40 g of soy protein (about ¼ cup of shelled edamame) or milk-based protein for three months. At the study's end, pain was reduced for those who ate soy protein but not for those in the milk protein group. "I'm talking about tofu, tempeh, other fermented forms of whole soy—not soy protein isolates, which you commonly see in processed snacks," says James N. Dillard, MD, author of The Chronic Pain Solution . Cooking with tofu is simple as long as you know the basics. Silken tofu is soft and often used in creamy dressings, soups, and desserts; firm tofu is typically cooked like meat—say, marinated and grilled.