Primobolan is often stacked with other steroids to provide more pleasing results to the user. During a cutting cycle the product could be stacked with a non-aromatising androgen to aid muscle hardness whilst keeping a very defined look with little water retention. Others may find primobolan a nice compound to add to their usual Testosterone course to add to the anabolic nature of the cycle, whilst not adding too much to side effects. This may be useful for those who have found their tolerance dosage with Testosterone but wish to add another compound to their stack to aid gains.
A number of investigators have reported on a rather rare syndrome of excess aromatase activity. In boys, it can lead to gynecomastia , and in girls to precocious puberty and gigantomastia . In both sexes, early epiphyseal closure leads to short stature. This condition is due to mutations in the CYP19A1 gene which encodes aromatase.  It is inherited in an autosomal dominant fashion.  It has been suggested that the pharaoh Akhenaten and other members of his family may have suffered from this disorder,  but more recent genetic tests suggest otherwise.  It is one of the causes of familial precocious puberty—a condition first described in 1937.