The precise mechanism through which fluticasone propionate affects rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. In 7 trials in adults, fluticasone propionate nasal spray has decreased nasal mucosal eosinophils in 66% of patients (35% for placebo) and basophils in 39% of patients (28% for placebo). The direct relationship of these findings to long-term symptom relief is not known.
You may be tempted to stop using ClariSpray ® Nasal Allergy Spray when you start to feel better. It’s important you keep using ClariSpray ® Nasal Allergy Spray daily as long as you’re exposed to allergens that bother you, like pollen, mold, dust or pet dander. This way, you’ll keep feeling relief. If you suffer allergy symptoms only during certain times, like when pollen levels are high, you may stop using ClariSpray ® Nasal Allergy Spray when that time ends. If you are age 12 or older and need to use daily for longer than 6 months or age 4–11 and need to use for longer than 2 months a year, check with your doctor.