Acetaminophen (also known as paracetamol, and commonly branded as Tylenol or Excedrin) was introduced in 1955. It has about the same pain-relieving power as aspirin for pains not caused by inflammation, but is slightly less effective for inflammatory pain. This is because it doesn’t alleviate inflammation, and is probably not as effective with menstrual cramps as ibuprofen. Of all the analgesics, acetaminophen is the least likely to be a stomach irritant. However, taking more than 325 mg of acetaminophen at a time, taking more than one type of medication that contains acetaminophen, or taking it with alcohol can lead to severe liver damage — which can require a liver transplant or even result in death.